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Put two entries side by side — evidence, mechanism, risks, and community claims.
HGH (Somatropin)
Clinical
Restricted
Summary
Recombinant human growth hormone (191 amino acids) — pharmaceutical somatropin exists for approved deficiency indications; research vials are a separate gray-market category.
Categories
Growth Hormone Axis, Performance
Mechanism
Binds GHR to activate JAK2–STAT5 and related pathways, increasing IGF-1 production (especially hepatic), promoting lipolysis, protein synthesis, and growth-plate activity in pediatrics.
Half-life
~2–3 hours IV; longer biological effect via IGF-1 axis
Routes
Subcutaneous injection; Intramuscular injection
Legal / access
FDA-approved somatropin products exist for labeled indications. Unprescribed HGH is restricted; research vials are not approved drugs and carry legal risk.
Key risks
- Edema
- Arthralgia
- Carpal tunnel
- Insulin resistance
Common claims
- Fat loss while preserving lean mass
- Recovery and sleep quality
- Anti-aging / IGF-1 elevation
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