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Semaglutide
Clinical
FDA-approved (specific use)
Summary
Long-acting GLP-1 receptor agonist; FDA-approved for type 2 diabetes and chronic weight management.
Categories
Metabolic & Body Comp
Mechanism
GLP-1 receptor agonism in brain and gut reduces hunger and postprandial glucose excursions; promotes weight loss primarily via reduced energy intake.
Half-life
~1 week (weekly injection formulations)
Routes
Subcutaneous injection; Oral
Legal / access
FDA-approved as prescription medicine for defined indications. Counterfeit and unapproved compounded products have been a major safety issue.
Key risks
- Nausea, vomiting, constipation/diarrhea
- Gallbladder issues
- Muscle loss if protein/training neglected
- Rare pancreatitis / thyroid C-cell tumor warnings per label
Common claims
- Rapid fat loss with appetite control
- Food-noise reduction
- Metabolic reset narratives
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