Semax
Also known as Met-Glu-His-Phe-Pro-Gly-Pro · ACTH(4-10) analog
New
Reconstitution & dosing guide
5 mg · 10 mg vial sizes — research phases, recon steps, and a live unit calculator.
Available sizes & price
Catalog only10mg x 10 vials
Semax (XA10) · Not in current stock
$30 / vial
5mg x 10 vials
Semax (XA5) · Not in current stock
$20 / vial
Prices per vial · Research use only · Not medical advice.
ACTH-derived nootropic peptide used in Russia for stroke and cognitive support; popular nasal nootropic abroad.
How to picture it
Learning and recovery in the brain depend on growth signals like BDNF and its receptor TrkB. Semax is an ACTH fragment engineered to push that neurotrophic pathway without acting like full ACTH (so it doesn't drive cortisol the same way). Picture a "build and stabilize synapses" memo to the hippocampus and related circuits — fertilizer for learning and resilience pathways, used in research and in Russian clinical practice for cognitive and stroke-recovery contexts — not a caffeine-like stimulant.
Research focus & benefits
- BDNF/TrkB and synaptic plasticity research
- Cognitive and attention pathway studies
- Stroke recovery literature (Russian clinical tradition)
- Nootropic research without ACTH cortisol effects
Benefits describe research interest and pathway rationale — not guaranteed outcomes or medical advice. Research use only.
Overview
Semax is a heptapeptide analog of a fragment of ACTH with negligible hormonal steroidogenic activity. Russian medicine has used it for cerebrovascular and cognitive indications. Biohackers seek focus, neuroprotection, and post-stress recovery via nasal sprays (including N-Acetyl Semax variants).
Mechanism
Upregulates BDNF and neurotrophic signaling; modulates monoamines; neuroprotective effects in ischemia models.
Research uses
- Ischemic stroke (regional clinical use)
- Optic nerve / cognitive research
- Neuroprotection studies
Research dosing notes
N-Acetyl and Amidate analogs appear in research markets with different potency claims.
Half-life / kinetics
Short; repeated nasal dosing
Common research routes
Reported considerations
- Nasal irritation
- Overstimulation if stacked with stimulants
- Blood pressure caution
Contraindications / cautions
- Acute psychiatric instability
- Pregnancy
- Uncontrolled hypertension caution
Common research stacks
- Selank
- Lion mane / lifestyle nootropics
- Sleep optimization
Legal / access note
Used pharmaceutically in Russia; research chemical status in many other countries.