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ACTH 1-39
Clinical
Research chemical
Summary
Full-length adrenocorticotropic hormone peptide used in endocrine and stress-axis research; parent pathway for several nootropic ACTH analogs.
Categories
Cognitive & Nootropic, Performance
Mechanism
Binds melanocortin receptors (notably MC2R on adrenal cortex) to drive steroidogenesis. Shorter N-terminal fragments retain CNS melanocortin activity with less adrenal drive — the rationale behind Semax/ACTH(4-10) nootropics.
Half-life
Short (minutes to hours depending on formulation)
Routes
Intramuscular injection; Subcutaneous injection; Intravenous
Legal / access
Pharmaceutical ACTH exists for specific endocrine tests/indications; research-catalog 1-39 is not an approved consumer product.
Key risks
- Cortisol elevation
- Hypertension risk
- Hyperglycemia
- Immune modulation
Common claims
- Endocrine reset narratives
- ACTH stimulation test context
- Cognitive stack parent pathway
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