Compare peptides
Put two entries side by side — evidence, mechanism, risks, and community claims.
Cortagen (AEDP)
Preclinical
Research chemical
Summary
Khavinson tetrapeptide bioregulator (Ala-Glu-Asp-Pro) developed as a cerebral-cortex-targeted short peptide for neuroprotection and cortical gene regulation research.
Categories
Cognitive & Nootropic, Longevity
Mechanism
Proposed direct chromatin/DNA interaction in cortical neurons with tissue-selective transcriptional modulation. Shares Ala-Glu-Asp core with Epitalon; proline C-terminus is associated with structural stability. Microarray work from the originating group reported differential expression of dozens to ~100+ genes after exposure.
Half-life
Short plasma half-life (ultrashort peptide)
Routes
Subcutaneous injection
Legal / access
Research bioregulator; not an approved nootropic or stroke drug in the US.
Key risks
- Limited independent safety data
- Unknown CNS drug interactions
Common claims
- Cognitive aging support
- Nerve repair narratives
- Nootropic bioregulator stack
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