CagriSema 20 mg
Educational recon guide for a 20 mg equal Cagrilintide + Semaglutide research blend (10 mg each) and weekly total-blend unit mapping. Research use only.
Vial size
Same research phases — calculator defaults and unit math match the selected vial strength.
Vial
20 mg
Your BAC water
2 mL
Concentration
10.00 mg/mL
Per unit
~100.0 mcg
Frequency
Once weekly (same weekday)
Route
Subcutaneous
Blend composition
Fixed ratio in every draw. Per-draw amounts follow your calculator dose (0.50 mg total blend).
| Component | In vial | Share | Per draw |
|---|---|---|---|
| Cagrilintide | 10 mg | 50.0% | 250 mcg |
| Semaglutide | 10 mg | 50.0% | 250 mcg |
Total listed mass 20 mg. Step 2 of the calculator is total blend — not one peptide alone.
Live reconstitution calculator
Defaults match this guide (20 mg + 2 mL BAC). Change water or dose and the unit tables below update automatically.
Step 1
Reconstitution
Peptide amount in the vial and how much bacteriostatic water you add.
Step 2
Your dose
This guide uses microgram-scale research doses — quick picks are in mcg (100 mcg = 0.1 mg).
Quick select (mcg) — switch units or type any value
Suggested: 30-unit barrel (smallest that fits this draw).
Your draw
Results
Total draw
5 units
Volume
0.050 mL
Doses per vial
40
Syringes needed
1
Barrel
30-unit
Fits one syringe?
Yes
30-unit · 0.3 mL
Filled to 5 u
Fill one 30-unit U-100 syringe to about 5 units (0.050 mL).
Weekly research phases
Units and volumes recompute from your Step 1 concentration (2 mL BAC → 10.00 mg/mL · 100.0 mcg/unit).
Standard titration
Investigational CagriSema programs titrate both amylin and GLP-1 components (often toward ~2.4 mg of each weekly after multi-step escalation). This fixed equal-mass vial keeps a 1:1 ratio in every draw — total blend mg = 2 × each peptide mg.
| Phase | Weekly dose | Units | Volume |
|---|---|---|---|
| Weeks 1–4 | 500 mcg0.5 mg | 5 u | 0.05 mL0.5 mg total ≈ 0.25 mg cagri + 0.25 mg sema |
| Weeks 5–8 | 1 mg1,000 mcg | 10 u | 0.10 mL1 mg total ≈ 0.5 + 0.5 mg |
| Weeks 9–12 | 2 mg2,000 mcg | 20 u | 0.20 mL2 mg total ≈ 1 + 1 mg |
| Weeks 13–16 | 3.40 mg3,400 mcg | 34 u | 0.34 mL3.4 mg total ≈ 1.7 + 1.7 mg |
| Weeks 17+ | 4.80 mg4,800 mcg | 48 u | 0.48 mL4.8 mg total ≈ 2.4 + 2.4 mg — mirrors common dual target discussion (if vial size allows) |
Advanced / higher-end
Faster escalation discussed in research communities — not a clinical recommendation
| Phase | Weekly dose | Units | Volume |
|---|---|---|---|
| Mid hold · 2.4 mg total weekly | 2.40 mg2,400 mcg | 24 u | 0.24 mL1.2 + 1.2 mg each — intermediate educational hold |
Supplies planner
Using the guide’s phase ladder (500 mcg → 1 mg → 2 mg weekly (phase ladder)) over a 12-week schedule. Set a dose in Step 2 to plan supplies at your own amount.
Your recon
2 mL · 10.00 mg/mL
Dose in plan
Phase ladder
Syringe size
100-unit
Horizon
12-week schedule
CagriSema 20 mg vials
1 vial
~14 mg mg total peptide over this 12-week schedule at 500 mcg → 1 mg → 2 mg weekly (phase ladder). Each vial holds 20 mg.
Bacteriostatic water
1 × 3 mL bottle
2 mL BAC per vial × 1 vial = 2.0 mL total. Buy as 1× 3 mL bottle or 1× 10 mL bottle (whichever you stock).
U-100 insulin syringes (100-unit)
12+ syringes
About one 100-unit syringe per injection for this schedule. Keep a few spares.
Alcohol swabs & sharps
~26 swabs · 1 sharps container
Wipe vial stopper and injection site each time. Dispose needles in a proper sharps container.
Reconstitution steps
- Allow the lyophilized 20 mg Cagri+Sema blend vial and bacteriostatic water to reach room temperature.
- Draw 2.0 mL bacteriostatic water (default for this guide).
- Inject BAC slowly down the inner wall of the vial — avoid blasting the powder cake.
- Gently swirl or roll until the solution is clear. Do not shake hard (foaming).
- Label with recon date and concentration (e.g. "10.0 mg/mL total — 2 mL BAC").
- Refrigerate at 2–8 °C (35–46 °F), protected from light. Prefer using a reconstituted multi-dose vial within ~28 days with sterile technique.
Storage
Lyophilized
Keep dry powder cold and dark when possible (−20 °C / −4 °F preferred for long-term research stock).
Reconstituted
Refrigerate at 2–8 °C (35–46 °F). Avoid freeze–thaw of the working solution. Prefer finishing within ~28 days.
- ·Write recon date and BAC volume on the label.
- ·Protect from light during storage.
- ·Discard if cloudy, particulates, or odd odor appear after reconstitution.
Protocol notes
- ·Tables use TOTAL BLEND milligrams — fixed 50% cagrilintide / 50% semaglutide by mass.
- ·You cannot independently titrate cagri vs sema from a fixed equal blend without separate vials.
- ·Research use only — not approved combination product.
Research context & considerations
CagriSema combines long-acting amylin analogue cagrilintide with GLP-1 agonist semaglutide. Large outcome programs have reported substantial weight-loss signals for the dual approach. Research-market dual vials are not clinical drug product.
- ·GI effects can be additive when stacking amylin + GLP-1 pathways.
- ·GLP-1-class label cautions (e.g. MTC/MEN2 discussions on approved products) remain relevant framing.
- ·Not FDA-approved as a research-vial consumer medicine.
- ·Pregnancy and pediatric use out of scope.
Catalog match
Cagri+sema (10mg+10mg)
20mg x 10 vials · from $165