KPV
Also known as Lys-Pro-Val · α-MSH fragment
New
Reconstitution & dosing guide
5 mg · 10 mg vial sizes — research phases, recon steps, and a live unit calculator.
Available sizes & price
Catalog only10mg x 10 vials
KPV (KPV10) · Not in current stock
$40 / vial
5mg x 10 vials
KPV (KPV5) · Not in current stock
$30 / vial
250mcg x 60
KPV Capsules · Not in current stock
$20 / vial
Prices per vial · Research use only · Not medical advice.
Anti-inflammatory tripeptide fragment of alpha-MSH studied for gut and skin inflammation.
How to picture it
Inflammation is often a megaphone (NF-κB) that drowns out repair. KPV, a tiny tripeptide from the α-MSH family, is studied for entering cells and turning down that megaphone in epithelial tissue — without the tanning effects of full melanocortin stimulation. Picture a quiet switch on the inflammatory loudspeaker so healing can be heard. That "calm the alarm" idea is why it shows up in gut and barrier inflammation research and in stacks like KLOW.
Research focus & benefits
- NF-κB and epithelial anti-inflammatory research
- Gut and barrier inflammation interest
- α-MSH fragment pathway studies without pigment effects
Benefits describe research interest and pathway rationale — not guaranteed outcomes or medical advice. Research use only.
Overview
KPV is a C-terminal tripeptide of alpha-melanocyte-stimulating hormone with anti-inflammatory properties and less pigmentation activity than full melanocortin agonists. It is discussed for IBD models, gut healing stacks, and topical skin inflammation.
Mechanism
Inhibits inflammatory signaling (including NF-κB related pathways in research); melanocortin-related anti-inflammatory effects with reduced MC1R tanning activity.
Research uses
- IBD / colitis models
- Cutaneous inflammation
- Antimicrobial peptide synergy research
Research dosing notes
Oral and injectable research routes both appear in community protocols.
Half-life / kinetics
Short
Common research routes
Reported considerations
- Limited data
- Mild GI or injection irritation possible
Contraindications / cautions
- Serious IBD needs gastroenterology care
- Pregnancy
Common research stacks
- BPC-157
- GHK-Cu topical
- Elimination diets for gut issues
Legal / access note
Research peptide; not a substitute for standard IBD therapy.