Matrixyl (Palmitoyl Pentapeptide-4)
Also known as Matrixyl · Palmitoyl Pentapeptide-4 · Pal-KTTKS
New
Reconstitution & dosing guide
10 mg vial — research phases, recon steps, and a live unit calculator.
Available sizes & price
Catalog only10mg x 10 vials
Matrixyl · Not in current stock
$25 / vial
Prices per vial · Research use only · Not medical advice.
Palmitoylated pentapeptide widely used in cosmetic anti-aging formulations to stimulate collagen and extracellular-matrix remodeling signals.
How to picture it
Fibroblasts respond to damage tickets. Matrixyl is a palmitoylated signal peptide used in topical research/cosmetics to present a matrix-repair order — encouraging collagen and extracellular-matrix programs as if renovation was already approved. Picture a local sticky note on dermal cells: recruit the skin's own construction crew rather than only moisturizing the finished surface.
Research focus & benefits
- Topical collagen and matrix remodeling research
- Cosmetic peptide fibroblast signaling studies
- Extracellular-matrix production interest
Benefits describe research interest and pathway rationale — not guaranteed outcomes or medical advice. Research use only.
Overview
Matrixyl (palmitoyl pentapeptide-4, often Pal-KTTKS) is one of the best-known cosmetic signal peptides. The palmitoyl group improves skin delivery. It is primarily a topical cosmetic ingredient; research vials in peptide catalogs are secondary to skincare product use.
Mechanism
Fragment related to type I collagen propeptide signaling; stimulates fibroblasts to increase collagen I/III, fibronectin, and matrix proteins in vitro and in cosmetic clinical photography studies.
Research uses
- Cosmetic collagen-stimulation trials
- Anti-wrinkle cream formulation science
- ECM remodeling in dermal fibroblasts
Research dosing notes
Typical cosmetic leave-on concentrations. Injectable use is not the established evidence path.
Half-life / kinetics
Topical local kinetics
Common research routes
Reported considerations
- Mild irritation
- Sensitization rare
Contraindications / cautions
- Broken skin
- Patch-test new formulas
Common research stacks
- GHK-Cu
- Snap-8
- Retinoids (cosmetic)
Legal / access note
Established cosmetic ingredient; research vials are not drug products.