MOTS-c
Also known as Mitochondrial ORF of the Twelve S rRNA type-c
New
Reconstitution & dosing guide
10 mg · 20 mg · 40 mg vial sizes — research phases, recon steps, and a live unit calculator.
Available sizes & price
Catalog only10mg x 10 vials
MOTS-c (Human) (MS10) · Not in current stock
$30 / vial
40mg x 10 vials
MOTS-c (Human) (MS40) · Not in current stock
$75 / vial
20mg x 10 vials
MOTS-c (Human) (MS20) · Not in current stock
$50 / vial
Prices per vial · Research use only · Not medical advice.
Mitochondria-encoded peptide linked to exercise-mimetic metabolic regulation in research.
How to picture it
Picture each cell as a small factory with two control rooms. The mitochondria are the power plant in the basement. MOTS-c is a short message the power plant itself writes — it is encoded in mitochondrial DNA, not the main nuclear genome. When energy is tight (hard training, low fuel, metabolic stress), that message first changes the factory's fuel accounting: it interferes with the folate / one-carbon pathway enough that AICAR piles up. AICAR is like a "we're running low on power" alarm that flips on AMPK, the cell's master energy switch. With AMPK on, the cell shifts toward efficient fuel use — more glucose uptake, more fat oxidation. Then the unusual part: with AMPK's help, MOTS-c can travel up to the main control room — the nucleus — and sit near antioxidant-response DNA regions, helping turn up stress-adaptation genes. So MOTS-c is not a stimulant and not a caffeine-style fat burner. It is a mitochondria-to-nucleus courier that (1) trips the energy alarm and (2) helps rewrite short-term gene instructions for metabolic stress — which is why researchers call it exercise- and stress-adaptive.
Research focus & benefits
- AMPK and metabolic stress-adaptation research
- Insulin sensitivity and exercise-mimetic pathway studies
- Mitochondrial–nuclear communication science
- Obesity and metabolic-disease model literature
Benefits describe research interest and pathway rationale — not guaranteed outcomes or medical advice. Research use only.
Overview
MOTS-c is a 16-amino-acid peptide encoded in the mitochondrial genome. Research suggests roles in insulin sensitivity, metabolic stress adaptation, and exercise-related pathways. Longevity and metabolic biohackers track it closely; human clinical evidence is still developing.
Mechanism
Acts in nucleus under metabolic stress to regulate gene expression; associated with AMPK-related metabolic benefits in models; exercise-mimetic framing in literature.
Research uses
- Insulin resistance models
- Aging metabolism
- Exercise physiology research
Research dosing notes
Research protocols vary; often intermittent rather than daily forever.
Half-life / kinetics
Short to intermediate; protocol-dependent
Common research routes
Reported considerations
- Limited human data
- Injection-site reactions
- Unknown chronic risks
Contraindications / cautions
- Pregnancy
- Serious illness without clinician
- Replacement for exercise
Common research stacks
- SS-31
- Humanin
- Zone 2 training (actual exercise still matters)
Legal / access note
Research peptide; not an approved metabolic drug.