Sermorelin
Also known as GRF 1-29 · Geref (historical brand)
New
Reconstitution & dosing guide
2 mg · 5 mg · 10 mg · 15 mg vial sizes — research phases, recon steps, and a live unit calculator.
Available sizes & price
Catalog only10mg x 10 vials
Sermorelin Acetate (SMO10) · Not in current stock
$50 / vial
15mg x 10 vials
Sermorelin Acetate (SMO15) · Not in current stock
$70 / vial
2mg x 10 vials
Sermorelin Acetate (SMO2) · Not in current stock
$20 / vial
5mg x 10 vials
Sermorelin Acetate (SMO5) · Not in current stock
$35 / vial
Prices per vial · Research use only · Not medical advice.
GHRH (1-29) analog historically used diagnostically and therapeutically to stimulate endogenous GH.
How to picture it
Sermorelin is a short GHRH(1-29) fragment that mimics the natural "release GH" instruction from the hypothalamus to the pituitary. Picture pressing the pituitary's own button instead of delivering finished growth hormone into the blood. Feedback loops stay in play, release stays pulse-shaped when the axis is responsive, and the educational frame is physiologic GH engagement rather than flat external replacement — historically used in diagnostic and pediatric contexts.
Research focus & benefits
- Physiologic GH/IGF-1 elevation when pituitary is responsive
- Sleep and recovery research interest
- More feedback-preserving framing than rHGH
- Historical clinical/diagnostic use context
Benefits describe research interest and pathway rationale — not guaranteed outcomes or medical advice. Research use only.
Overview
Sermorelin is a shortened analog of endogenous GHRH. It previously had FDA approval (as Geref) for diagnostic testing and pediatric GH deficiency indications in some contexts, though commercial availability has shifted. In longevity clinics it is still prescribed by some practitioners as a comparatively physiologic GH-axis support option.
Mechanism
Stimulates pituitary GH release via GHRH receptors, preserving feedback loops more closely than exogenous rHGH.
Research uses
- GH stimulation testing
- Adult GH optimization in clinic settings
- Sleep and body-composition support discussions
Research dosing notes
Clinic protocols typically use nightly subcutaneous dosing. Requires medical supervision where prescribed.
Half-life / kinetics
Short (minutes to under an hour)
Common research routes
Reported considerations
- Flushing
- Injection-site pain
- Headache
- Hyperactivity or sleep changes
Contraindications / cautions
- Active cancer
- Pregnancy
- Untreated pituitary disorders
Common research stacks
- Ipamorelin
- Lifestyle sleep optimization
- Resistance training
Legal / access note
Has a clinical history of approval for specific uses; current compounding and availability vary. Not a free research free-for-all in regulated clinics.