Growth Hormone Axis
Metabolic & Body Comp
Clinical
FDA-approved (specific use)

Tesamorelin

Also known as Egrifta · TH9507

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Reconstitution & dosing guide

2 mg · 5 mg · 10 mg · 20 mg vial sizes — research phases, recon steps, and a live unit calculator.

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Available sizes & price

Catalog only

10mg x 10 vials

Tesamorelin (TSM10) · Not in current stock

$65 / vial

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2mg x 10 vials

Tesamorelin (TSM2) · Not in current stock

$35 / vial

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20mg x 10 vials

Tesamorelin (TSM20) · Not in current stock

$120 / vial

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5mg x 10 vials

Tesamorelin (TSM5) · Not in current stock

$45 / vial

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Prices per vial · Research use only · Not medical advice.

FDA-approved GHRH analog for reducing excess abdominal fat in HIV-associated lipodystrophy; also discussed for visceral fat in biohacking circles.

How to picture it

Tesamorelin is a stabilized GHRH analog — still a formal "release GH" request to the pituitary — with clinical data on reducing deep visceral abdominal fat in a defined approved population. Picture a pituitary-level GH instruction whose research story reaches beyond hormone numbers into body-composition biology: GH/IGF-1 tone linked to visceral adipose pathways. Same axis door as other GHRH analogs, with a more specific visceral-fat research chapter.

Research focus & benefits

  • Visceral adipose reduction research (HIV lipodystrophy literature)
  • GH and IGF-1 elevation studies
  • Metabolic marker and body-composition interest
  • FDA-approved product exists for a defined indication

Benefits describe research interest and pathway rationale — not guaranteed outcomes or medical advice. Research use only.

Overview

Tesamorelin is a stabilized GHRH analog approved as Egrifta for reduction of excess visceral adipose tissue in specific HIV patient populations. Because of its effect on visceral fat and IGF-1, it is frequently discussed off-label in performance and longevity communities, though off-label use carries medical and legal considerations.

Mechanism

GHRH receptor agonist increasing endogenous GH and IGF-1, which can reduce visceral adipose tissue in indicated patients.

Research uses

  • HIV-associated lipodystrophy (approved indication)
  • Visceral adiposity research
  • Cognitive and NAFLD exploratory research

Research dosing notes

Prescription product uses daily subcutaneous dosing per label for indicated patients. Off-label self-experimentation is not advised.

Open full reconstitution & dosing guide →

Half-life / kinetics

~26–38 minutes (but clinical effects via GH/IGF-1 axis)

Common research routes

Subcutaneous injection

Reported considerations

  • Arthralgia
  • Peripheral edema
  • Injection-site reactions
  • Elevated IGF-1
  • Glucose intolerance risk

Contraindications / cautions

  • Active malignancy
  • Disruption of the hypothalamic-pituitary axis
  • Pregnancy
  • Known hypersensitivity

Common research stacks

  • Lifestyle deficit
  • Resistance training
  • Sometimes CJC/IPA discussions (clinic-dependent)

Legal / access note

FDA-approved for a specific HIV lipodystrophy indication. Off-label and research-market versions should not be confused with the approved product.