PNC-27
Also known as PNC-27 · p53-HDM2 anticancer peptide
New
Reconstitution & dosing guide
5 mg vial — research phases, recon steps, and a live unit calculator.
Available sizes & price
Catalog only5mg x 10 vials
PNC-27 · Not in current stock
$45 / vial
Prices per vial · Research use only · Not medical advice.
Chimeric peptide combining a p53 HDM-2-binding segment with a membrane-penetration motif; studied for selective cancer cell membrane disruption in preclinical oncology research.
How to picture it
A research peptide designed to recognize HDM-2 on certain cancer cell surfaces and disrupt their membranes. Picture a targeted hole-puncher aimed at marked tumor cells in preclinical models — experimental oncology tool concept: precise, high-stakes research only.
Research focus & benefits
- Experimental oncology membrane-disruption research
- HDM-2 surface-targeting studies
- Preclinical selective cancer-cell models
Benefits describe research interest and pathway rationale — not guaranteed outcomes or medical advice. Research use only.
Overview
PNC-27 was designed to target HDM-2-expressing cancer cell membranes and induce necrosis-like pore formation. Preclinical papers report selective killing of various tumor lines with less effect on untransformed cells. It is an experimental oncology research peptide — not an anti-aging supplement.
Mechanism
Binds membrane-associated HDM-2 on cancer cells; transmembrane domain inserts and disrupts membrane integrity leading to cell death. Distinct from classic nuclear p53 reactivation drugs.
Research uses
- In vitro cancer cell line cytotoxicity panels
- Xenograft tumor models
- HDM-2 membrane biology research
Research dosing notes
Oncology research protocols only. No approved human dosing for wellness.
Half-life / kinetics
Research-dependent
Common research routes
Reported considerations
- Unknown systemic toxicity
- Potential off-target membrane effects
Contraindications / cautions
- Self-treatment of cancer is dangerous — oncology care only
- Pregnancy
Legal / access note
Experimental anticancer research peptide. Not approved cancer therapy. Not for self-medication.